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KMID : 0359420230410020107
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Korean Journal of Sports Medicine
2023 Volume.41 No. 2 p.107 ~ p.110
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Exercise Capacity and Pulmonary Capacitance Are Attenuated in Patients with Nonalcoholic Steatohepatitis
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Donkor Joshua
Carlson Alex R.
Ziegler Briana L.
Johnston Jessica I.
Cho Jin-Kyung
Johnson Bruce D.
Kim Chul-Ho
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Abstract
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Purpose: The study was to investigate exercise capacity (peak oxygen uptake [peak VO2]) and pulmonary capacitance (GXcap), which is an estimate of pulmonary vascular capacitance, in patients with nonalcoholic steatohepatitis (NASH).
Methods: This study utilized a database of patients with NASH (n=26 [17 male and 9 female], aged 58.9±4.3 years) and healthy individuals (n=23 [12 male and 11 female, aged 58.6±7.9 years) who underwent a maximal exercise test on a recumbent cycle ergometer (Corival; Lode) in our laboratory. During cardiopulmonary exercise tests, breathing patterns and respiratory gas exchange including breathing efficiency (VE/VCO2) and end-tidal CO2 (PETCO2) were measured. In addition, peak VO2 was obtained via averaging the last 30 seconds at peak level and GXcap was obtained by calculation as follows: GXcap=oxygen pulse (O2 pulse)×PETCO2.
Results: The NASH group demonstrated reduced peak VO2 relative to the healthy group (17.5±8.4 mL/kg/min vs.
34±10.2 mL/kg/min, respectively; p＜0.05). In addition, there was a higher VE/VCO2 relationship in the NASH group relative to the healthy group (34.9±5.5 vs. 32.2±4.0, respectively; p＜0.05) and lower PETCO2 in the NASH group compared to the healthy group (32.8±4.0 mm Hg vs. 35.3±3.8 mm Hg, respectively; p＜0.05). Furthermore, the NASH group showed lower GXcap than the healthy group (456±150 vs. 551±202, respectively; p＜0.05).
Conclusion: Patients with NASH had reduced exercise capacity and pulmonary vascular capacitance relative to age-matched healthy adults and this may contribute to pulmonary pathophysiology in NASH.
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KEYWORD
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Non-alcoholic fatty liver disease, Pulmonary capacitance, Exercise capacity
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